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Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity
The mutant gdPT R9K/E129G is a genetically detoxified variant of the pertussis toxin (PTx) and represents an attractive candidate for the development of improved pertussis vaccines. The impact of the mutations on the overall protein structure and its immunogenicity has remained elusive. Here we pres...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406505/ https://www.ncbi.nlm.nih.gov/pubmed/32759959 http://dx.doi.org/10.1038/s42003-020-01153-3 |