PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation

PRMT5 participates in various cellular processes, including transcription regulation, signal transduction, mRNA splicing, and DNA repair; however, its mechanism of regulation is poorly understood. Here, we demonstrate that PRMT5 is phosphorylated at residue Y324 by Src kinase, a negative regulator o...

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Detalles Bibliográficos
Autores principales: Hwang, Jee Won, Kim, Su-Nam, Myung, Nayeon, Song, Doona, Han, Gyoonhee, Bae, Gyu-Un, Bedford, Mark T., Kim, Yong Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406651/
https://www.ncbi.nlm.nih.gov/pubmed/32759981
http://dx.doi.org/10.1038/s42003-020-01157-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406651/
https://www.ncbi.nlm.nih.gov/pubmed/32759981
http://dx.doi.org/10.1038/s42003-020-01157-z

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