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PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation
PRMT5 participates in various cellular processes, including transcription regulation, signal transduction, mRNA splicing, and DNA repair; however, its mechanism of regulation is poorly understood. Here, we demonstrate that PRMT5 is phosphorylated at residue Y324 by Src kinase, a negative regulator o...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406651/ https://www.ncbi.nlm.nih.gov/pubmed/32759981 http://dx.doi.org/10.1038/s42003-020-01157-z |