Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

Mitochondria are highly specialized organelles essential for the synapse, and their impairment contributes to the neurodegeneration in Alzheimer’s disease (AD). Previously, we studied the role of caspase-3–cleaved tau in mitochondrial dysfunction in AD. In neurons, the presence of this AD-relevant t...

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Detalles Bibliográficos
Autores principales: Quintanilla, Rodrigo A., Tapia-Monsalves, Carola, Vergara, Erick H., Pérez, María José, Aranguiz, Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406829/
https://www.ncbi.nlm.nih.gov/pubmed/32848607
http://dx.doi.org/10.3389/fncel.2020.00175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406829/
https://www.ncbi.nlm.nih.gov/pubmed/32848607
http://dx.doi.org/10.3389/fncel.2020.00175

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