Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study

BACKGROUND: The potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide. We sought to determine whether pharmacokinetic exposures of isoniazid and its metabolites were related to cellular oxidation/reduction status...

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Detalles Bibliográficos
Autores principales: Zentner, Isaac, Back, Hyun-moon, Kagan, Leonid, Subbian, Selvakumar, Nagajyothi, Jyothi, Srivastava, Shashikant, Pasipanodya, Jotam, Gumbo, Tawanda, Bisson, Gregory P., Vinnard, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406860/
https://www.ncbi.nlm.nih.gov/pubmed/32848735
http://dx.doi.org/10.3389/fphar.2020.01103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406860/
https://www.ncbi.nlm.nih.gov/pubmed/32848735
http://dx.doi.org/10.3389/fphar.2020.01103

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