The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism

Mitochondria are double-membrane organelles that continuously undergo fission and fusion. Outer mitochondrial membrane fusion is mediated by the membrane proteins mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2), carrying a GTP hydrolyzing domain (GTPase) and two coiled-coil repeats. The detailed mechanism...

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Detalles Bibliográficos
Autores principales: Tolosa-Díaz, Andrés, Almendro-Vedia, Víctor G., Natale, Paolo, López-Montero, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407159/
https://www.ncbi.nlm.nih.gov/pubmed/32708307
http://dx.doi.org/10.3390/biom10071085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407159/
https://www.ncbi.nlm.nih.gov/pubmed/32708307
http://dx.doi.org/10.3390/biom10071085

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