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The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism

Mitochondria are double-membrane organelles that continuously undergo fission and fusion. Outer mitochondrial membrane fusion is mediated by the membrane proteins mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2), carrying a GTP hydrolyzing domain (GTPase) and two coiled-coil repeats. The detailed mechanism...

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Detalles Bibliográficos
Autores principales:	Tolosa-Díaz, Andrés, Almendro-Vedia, Víctor G., Natale, Paolo, López-Montero, Iván
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407159/ https://www.ncbi.nlm.nih.gov/pubmed/32708307 http://dx.doi.org/10.3390/biom10071085

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