The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration

Cells migrating over 2D substrates are required to polymerise actin at the leading edge to form lamellipodia protrusions and nascent adhesions to anchor the protrusion to the substrate. The major actin nucleator in lamellipodia formation is the Arp2/3 complex, which is activated by the WAVE regulato...

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Detalles Bibliográficos
Autores principales: Whitelaw, Jamie A., Swaminathan, Karthic, Kage, Frieda, Machesky, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407199/
https://www.ncbi.nlm.nih.gov/pubmed/32646006
http://dx.doi.org/10.3390/cells9071635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407199/
https://www.ncbi.nlm.nih.gov/pubmed/32646006
http://dx.doi.org/10.3390/cells9071635

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