Digital Droplet PCR is a Specific and Sensitive Tool for Detecting IDH2 Mutations in Acute Myeloid LeuKemia Patients

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) interfere with cellular metabolism contributing to oncogenesis. Mutations of IDH2 at R140 and R172 residues are observed in 20% of acute myeloid leukemias (AML), and the availability of the IDH2 inhibitor Enasidenib made IDH2 mutational screening a cl...

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Detalles Bibliográficos
Autores principales: Grassi, Susanna, Guerrini, Francesca, Ciabatti, Elena, Puccetti, Riccardo, Salehzadeh, Serena, Metelli, Maria Rita, Di Vita, Alessia, Domenichini, Cristiana, Caracciolo, Francesco, Orciuolo, Enrico, Pelosini, Matteo, Mazzantini, Elisa, Rossi, Pietro, Mazziotta, Francesco, Petrini, Mario, Galimberti, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407265/
https://www.ncbi.nlm.nih.gov/pubmed/32629801
http://dx.doi.org/10.3390/cancers12071738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407265/
https://www.ncbi.nlm.nih.gov/pubmed/32629801
http://dx.doi.org/10.3390/cancers12071738

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