Cargando…

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder that causes the most prevalent dementia in the elderly people. Obesity and insulin resistance, which may cause major health problems per se, are risk factors for AD, and cytokines such as interleukin-6 (IL-6) have a role in these conditions. I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Escrig, Anna, Molinero, Amalia, Méndez, Brenda, Giralt, Mercedes, Comes, Gemma, Sanchis, Paula, Fernández-Gayol, Olaya, Giménez-Llort, Lydia, Becker-Pauly, Christoph, Rose-John, Stefan, Hidalgo, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407279/ https://www.ncbi.nlm.nih.gov/pubmed/32630818 http://dx.doi.org/10.3390/cells9071605

Ejemplares similares

Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer’s Disease
por: Comes, Gemma, et al.
Publicado: (2017)

Interleukin-6 Derived from the Central Nervous System May Influence the Pathogenesis of Experimental Autoimmune Encephalomyelitis in a Cell-Dependent Manner
por: Sanchis, Paula, et al.
Publicado: (2020)

Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice
por: Giménez-Llort, Lydia, et al.
Publicado: (2010)

A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis
por: Sanchis, Paula, et al.
Publicado: (2020)

Modeling Functional Limitations, Gait Impairments, and Muscle Pathology in Alzheimer’s Disease: Studies in the 3xTg-AD Mice
por: Castillo-Mariqueo, Lidia, et al.
Publicado: (2021)

Role of muscle IL-6 in gender-specific metabolism in mice
por: Molinero, Amalia, et al.
Publicado: (2017)

Impact of Chronic Risperidone Use on Behavior and Survival of 3xTg-AD Mice Model of Alzheimer’s Disease and Mice With Normal Aging
por: Torres-Lista, Virginia, et al.
Publicado: (2019)

Sex- and Neuropsychiatric-Dependent Circadian Alterations in Daily Voluntary Physical Activity Engagement and Patterns in Aged 3xTg-AD Mice
por: Alveal-Mellado, Daniel, et al.
Publicado: (2022)

Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers
por: Cañete, Toni, et al.
Publicado: (2021)

Genotype Load Modulates Amyloid Burden and Anxiety-Like Patterns in Male 3xTg-AD Survivors despite Similar Neuro-Immunoendocrine, Synaptic and Cognitive Impairments
por: Muntsant, Aida, et al.
Publicado: (2021)

Survival Curves and Behavioral Profiles of Female 3xTg-AD Mice Surviving to 18-Months of Age as Compared to Mice with Normal Aging
por: Torres-Lista, Virginia, et al.
Publicado: (2017)

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born
por: Gimenez-Llort, Lydia, et al.
Publicado: (2021)

Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice
por: Van der Jeugd, Ann, et al.
Publicado: (2018)

Vibrating Tail, Digging, Body/Face Interaction, and Lack of Barbering: Sex-Dependent Behavioral Signatures of Social Dysfunction in 3xTg-AD Mice as Compared to Mice with Normal Aging
por: Torres-Lista, Virginia, et al.
Publicado: (2019)

Long-term Treatment with Low-Dose Caffeine Worsens BPSD-Like Profile in 3xTg-AD Mice Model of Alzheimer’s Disease and Affects Mice with Normal Aging
por: Baeta-Corral, Raquel, et al.
Publicado: (2018)

Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer’s Disease from Premorbid to Advanced Stages and Compared to Normal Aging
por: Muntsant, Aida, et al.
Publicado: (2023)

Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging
por: Castillo-Mariqueo, Lidia, et al.
Publicado: (2022)

Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation
por: Llanos-González, Emilio, et al.
Publicado: (2023)

Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease
por: Mitrano, Darlene A., et al.
Publicado: (2021)

Astrocytic IL-6 Influences the Clinical Symptoms of EAE in Mice
por: Erta, Maria, et al.
Publicado: (2016)

Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3
por: Giménez-Llort, Lydia, et al.
Publicado: (2021)

Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer’s disease
por: Gloria, Yesica, et al.
Publicado: (2021)

Low-Dose Chidamide Treatment Displays Sex-Specific Differences in the 3xTg-AD Mouse
por: Dennison, Jessica, et al.
Publicado: (2023)

Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Stimmell, Alina C., et al.
Publicado: (2019)

Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Javonillo, Dominic I., et al.
Publicado: (2022)

Abnormal whisker movements in the 3xTg‐AD mouse model of Alzheimer's disease
por: Simanaviciute, Ugne, et al.
Publicado: (2022)

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice
por: Chen, Yanxing, et al.
Publicado: (2014)

Temporal and regional progression of Alzheimer’s disease‐like pathology in 3xTg‐AD mice
por: Belfiore, Ramona, et al.
Publicado: (2018)

Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice
por: Tan, Chenxi, et al.
Publicado: (2022)

Progressive Vascular Abnormalities in the Aging 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Jullienne, Amandine, et al.
Publicado: (2022)

Treatment of Alzheimer's Disease with Anti-Homocysteic Acid Antibody in 3xTg-AD Male Mice
por: Hasegawa, Tohru, et al.
Publicado: (2010)

DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice
por: Arsenault, Dany, et al.
Publicado: (2011)

Early and sustained altered expression of aging-related genes in young 3xTg-AD mice
por: Gatta, V, et al.
Publicado: (2014)

Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Kane, Alice E., et al.
Publicado: (2018)

Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer’s disease
por: Alkhouli, Mustafa F., et al.
Publicado: (2019)

Enhanced susceptibility of triple transgenic Alzheimer’s disease (3xTg-AD) mice to acute infection
por: Montacute, Rebecca, et al.
Publicado: (2017)

Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer’s Disease
por: Fagan, Steven G., et al.
Publicado: (2022)

Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research
por: Dennison, Jessica L., et al.
Publicado: (2021)

Retracted: Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice
por: Engineering, Journal of Healthcare
Publicado: (2023)

Endogenous Amyloid-formed Ca(2+)-permeable Channels in Aged 3xTg AD Mice
por: Li, Shuangtao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_45jl22a0g0o46k7i732qo04vqj