SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis

In contrast to normal regenerating tissue, resistance to Fas- and FasL-positive T cell-induced apoptosis were detected in myofibroblasts from fibrotic-lungs of humans and mice following bleomycin (BLM) exposure. In this study we show, decreased FLIP expression in lung-tissues with resolution of BLM-...

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Detalles Bibliográficos
Autores principales: Bulvik, Raanan, Breuer, Raphael, Dvir-Ginzberg, Mona, Reich, Eli, Berkman, Neville, Wallach-Dayan, Shulamit B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407379/
https://www.ncbi.nlm.nih.gov/pubmed/32630813
http://dx.doi.org/10.3390/biom10070996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407379/
https://www.ncbi.nlm.nih.gov/pubmed/32630813
http://dx.doi.org/10.3390/biom10070996

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