APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans

Genetic and epidemiological studies have found that variations in the amyloid precursor protein (APP) and the apoliopoprotein E (APOE) genes represent major modifiers of the progressive neurodegeneration in Alzheimer’s disease (AD). An extra copy of or gain-of-function mutations in APP correlate wit...

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Detalles Bibliográficos
Autores principales: Sae-Lee, Wisath, Scott, Luisa L., Brose, Lotti, Encarnacion, Aliyah J., Shi, Ted, Kore, Pragati, Oyibo, Lashaun O., Ye, Congxi, Rozmiarek, Susan K., Pierce, Jonathan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407474/
https://www.ncbi.nlm.nih.gov/pubmed/32580938
http://dx.doi.org/10.1534/g3.120.401486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407474/
https://www.ncbi.nlm.nih.gov/pubmed/32580938
http://dx.doi.org/10.1534/g3.120.401486

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