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APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans
Genetic and epidemiological studies have found that variations in the amyloid precursor protein (APP) and the apoliopoprotein E (APOE) genes represent major modifiers of the progressive neurodegeneration in Alzheimer’s disease (AD). An extra copy of or gain-of-function mutations in APP correlate wit...
Autores principales: | Sae-Lee, Wisath, Scott, Luisa L., Brose, Lotti, Encarnacion, Aliyah J., Shi, Ted, Kore, Pragati, Oyibo, Lashaun O., Ye, Congxi, Rozmiarek, Susan K., Pierce, Jonathan T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Genetics Society of America
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407474/ https://www.ncbi.nlm.nih.gov/pubmed/32580938 http://dx.doi.org/10.1534/g3.120.401486 |
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