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Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic doub...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407515/ https://www.ncbi.nlm.nih.gov/pubmed/32660124 http://dx.doi.org/10.3390/cells9071657 |
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author | Hanscom, Terrence McVey, Mitch |
author_facet | Hanscom, Terrence McVey, Mitch |
author_sort | Hanscom, Terrence |
collection | PubMed |
description | Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer. |
format | Online Article Text |
id | pubmed-7407515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74075152020-08-25 Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution Hanscom, Terrence McVey, Mitch Cells Review Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer. MDPI 2020-07-09 /pmc/articles/PMC7407515/ /pubmed/32660124 http://dx.doi.org/10.3390/cells9071657 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hanscom, Terrence McVey, Mitch Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title | Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_full | Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_fullStr | Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_full_unstemmed | Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_short | Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution |
title_sort | regulation of error-prone dna double-strand break repair and its impact on genome evolution |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407515/ https://www.ncbi.nlm.nih.gov/pubmed/32660124 http://dx.doi.org/10.3390/cells9071657 |
work_keys_str_mv | AT hanscomterrence regulationoferrorpronednadoublestrandbreakrepairanditsimpactongenomeevolution AT mcveymitch regulationoferrorpronednadoublestrandbreakrepairanditsimpactongenomeevolution |