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Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution

Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic doub...

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Detalles Bibliográficos
Autores principales: Hanscom, Terrence, McVey, Mitch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407515/
https://www.ncbi.nlm.nih.gov/pubmed/32660124
http://dx.doi.org/10.3390/cells9071657
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author Hanscom, Terrence
McVey, Mitch
author_facet Hanscom, Terrence
McVey, Mitch
author_sort Hanscom, Terrence
collection PubMed
description Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer.
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spelling pubmed-74075152020-08-25 Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution Hanscom, Terrence McVey, Mitch Cells Review Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer. MDPI 2020-07-09 /pmc/articles/PMC7407515/ /pubmed/32660124 http://dx.doi.org/10.3390/cells9071657 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hanscom, Terrence
McVey, Mitch
Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
title Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
title_full Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
title_fullStr Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
title_full_unstemmed Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
title_short Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution
title_sort regulation of error-prone dna double-strand break repair and its impact on genome evolution
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407515/
https://www.ncbi.nlm.nih.gov/pubmed/32660124
http://dx.doi.org/10.3390/cells9071657
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