Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters

Rivastigmine is a drug commonly used in the management of Alzheimer’s disease that shows bioavailability problems. To overcome this, the use of nanosystems, such as nanostructured lipid carriers (NLC), administered through alternative routes seems promising. In this work, we performed a double optim...

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Detalles Bibliográficos
Autores principales: Cunha, Sara, Costa, Cláudia Pina, Loureiro, Joana A., Alves, Jorge, Peixoto, Andreia F., Forbes, Ben, Sousa Lobo, José Manuel, Silva, Ana Catarina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407548/
https://www.ncbi.nlm.nih.gov/pubmed/32605177
http://dx.doi.org/10.3390/pharmaceutics12070599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407548/
https://www.ncbi.nlm.nih.gov/pubmed/32605177
http://dx.doi.org/10.3390/pharmaceutics12070599

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