Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations

SUMMARY STATEMENT: Pathogenic LRRK2 expression causes endolysosomal trafficking alterations by impairing RAB10 function, and these alterations are rescued by RAB29 independent of its Golgi localization. ABSTRACT: Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) cause familial Park...

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Detalles Bibliográficos
Autores principales: Rivero-Ríos, Pilar, Romo-Lozano, Maria, Fernández, Belén, Fdez, Elena, Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407826/
https://www.ncbi.nlm.nih.gov/pubmed/32709066
http://dx.doi.org/10.3390/cells9071719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407826/
https://www.ncbi.nlm.nih.gov/pubmed/32709066
http://dx.doi.org/10.3390/cells9071719

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