Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts

Oral cavity squamous cell carcinomas (OSCCs) are aggressive tumors, and their recurrence leads to poor prognosis and reduced survival rates. This study aimed to identify therapeutic targets and to evaluate the efficacy of targeted inhibitors in OSCC patient-derived xenograft (PDX) models. Herein, we...

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Detalles Bibliográficos
Autores principales: Yang, Chia-Yu, Liu, Chiao-Rou, Chang, Ian Yi-Feng, OuYang, Chun-Nan, Hsieh, Chia-Hsun, Huang, Yen-Lin, Wang, Chun-I, Jan, Fei-Wen, Wang, Wan-Ling, Tsai, Ting-Lin, Liu, Hsuan, Tseng, Ching-Ping, Chang, Yu-Sun, Wu, Chih-Ching, Chang, Kai-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408003/
https://www.ncbi.nlm.nih.gov/pubmed/32610557
http://dx.doi.org/10.3390/cancers12071726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408003/
https://www.ncbi.nlm.nih.gov/pubmed/32610557
http://dx.doi.org/10.3390/cancers12071726

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