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PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies. Nonetheless, it remains unclear how PTPN2 impacts the activation, survival, and...

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Detalles Bibliográficos
Autores principales:	Flosbach, Markus, Oberle, Susanne G., Scherer, Stefanie, Zecha, Jana, von Hoesslin, Madlaina, Wiede, Florian, Chennupati, Vijaykumar, Cullen, Jolie G., List, Markus, Pauling, Josch K., Baumbach, Jan, Kuster, Bernhard, Tiganis, Tony, Zehn, Dietmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408006/ https://www.ncbi.nlm.nih.gov/pubmed/32726622 http://dx.doi.org/10.1016/j.celrep.2020.107957

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