DLBCL Cells with Acquired Resistance to Venetoclax Are Not Sensitized to BIRD-2 But Can Be Resensitized to Venetoclax through Bcl-XL Inhibition

Anti-apoptotic Bcl-2-family members are frequently dysregulated in both blood and solid cancers, contributing to their survival despite ongoing oncogenic stress. Yet, such cancer cells often are highly dependent on Bcl-2 for their survival, a feature that is exploited by so-called BH3-mimetic drugs....

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Detalles Bibliográficos
Autores principales: Kerkhofs, Martijn, Vervloessem, Tamara, Stopa, Kinga B., Smith, Victoria M., Vogler, Meike, Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408247/
https://www.ncbi.nlm.nih.gov/pubmed/32708132
http://dx.doi.org/10.3390/biom10071081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408247/
https://www.ncbi.nlm.nih.gov/pubmed/32708132
http://dx.doi.org/10.3390/biom10071081

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