Structural Characterization of Co-Crystals of Chlordiazepoxide with p-Aminobenzoic Acid and Lorazepam with Nicotinamide by DSC, X-ray Diffraction, FTIR and Raman Spectroscopy

The low water solubility of benzodiazepines seriously affects their bioavailability and, in consequence, their biological activity. Since co-crystallization has been found to be a promising way to modify undesirable properties in active pharmaceutical ingredients, the objective of this study was to...

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Detalles Bibliográficos
Autores principales: Garbacz, Patrycja, Paukszta, Dominik, Sikorski, Artur, Wesolowski, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408267/
https://www.ncbi.nlm.nih.gov/pubmed/32659986
http://dx.doi.org/10.3390/pharmaceutics12070648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408267/
https://www.ncbi.nlm.nih.gov/pubmed/32659986
http://dx.doi.org/10.3390/pharmaceutics12070648

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