Combining CRISPR/Cas9-mediated knockout with genetic complementation for in-depth mechanistic studies in human ES cells

Gene regulatory networks that control pluripotency of human embryonic stem cells (hESCs) are of considerable interest for regenerative medicine. RNAi and CRISPR/Cas9 technologies have allowed the identification of hESC regulators on a genome-wide scale. However, these technologies are ill-suited for...

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Detalles Bibliográficos
Autores principales: Wang, Zheng, Zhang, Yan, Lee, Yu-Wei, Ivanova, Natalia B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408315/
https://www.ncbi.nlm.nih.gov/pubmed/30730211
http://dx.doi.org/10.2144/btn-2018-0115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408315/
https://www.ncbi.nlm.nih.gov/pubmed/30730211
http://dx.doi.org/10.2144/btn-2018-0115

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