Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action

There is a desperate need for novel and efficacious chemotherapeutic strategies for human brain cancers. There are abundant molecular alterations along the p53 and MDM2 pathways in human glioma, which play critical roles in drug resistance. The present study was designed to evaluate the in vitro and...

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Detalles Bibliográficos
Autores principales: Punganuru, Surendra R., Arutla, Viswanath, Zhao, Wei, Rajaei, Mehrdad, Deokar, Hemantkumar, Zhang, Ruiwen, Buolamwini, John K., Srivenugopal, Kalkunte S., Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408354/
https://www.ncbi.nlm.nih.gov/pubmed/32630235
http://dx.doi.org/10.3390/cells9071592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408354/
https://www.ncbi.nlm.nih.gov/pubmed/32630235
http://dx.doi.org/10.3390/cells9071592

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