IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

The efflux pump P-glycoprotein (P-gp) affects drug distribution after absorption in humans and animals. P-gp is encoded by the multidrug resistance gene (MDR1) gene in humans, while rodents (the most common preclinical animal model) express the two isoforms Mdr1a and Mdr1b. Differences in substrate...

Descripción completa

Detalles Bibliográficos
Autores principales: Saaby, Lasse, Trasborg, Josefine, Rasmussen, Mikkel A., Holst, Bjørn, Brodin, Birger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408396/
https://www.ncbi.nlm.nih.gov/pubmed/32708885
http://dx.doi.org/10.3390/pharmaceutics12070673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408396/
https://www.ncbi.nlm.nih.gov/pubmed/32708885
http://dx.doi.org/10.3390/pharmaceutics12070673

Ejemplares similares