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IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

The efflux pump P-glycoprotein (P-gp) affects drug distribution after absorption in humans and animals. P-gp is encoded by the multidrug resistance gene (MDR1) gene in humans, while rodents (the most common preclinical animal model) express the two isoforms Mdr1a and Mdr1b. Differences in substrate...

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Detalles Bibliográficos
Autores principales:	Saaby, Lasse, Trasborg, Josefine, Rasmussen, Mikkel A., Holst, Bjørn, Brodin, Birger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408396/ https://www.ncbi.nlm.nih.gov/pubmed/32708885 http://dx.doi.org/10.3390/pharmaceutics12070673

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