Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes

The MC1R/cAMP/MITF pathway is a key determinant for growth, differentiation, and survival of melanocytes and melanoma. MITF-M is the melanocyte-specific isoform of Microphthalmia-associated Transcription Factor (MITF) in human melanoma. Here we use two melanocyte cell lines to show that forced expre...

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Detalles Bibliográficos
Autores principales: Lavelle, Timothy J., Alver, Tine Norman, Heintz, Karen-Marie, Wernhoff, Patrik, Nygaard, Vegard, Nakken, Sigve, Øy, Geir Frode, Bøe, Sigurd Leinæs, Urbanucci, Alfonso, Hovig, Eivind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408466/
https://www.ncbi.nlm.nih.gov/pubmed/32605315
http://dx.doi.org/10.3390/cancers12071719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408466/
https://www.ncbi.nlm.nih.gov/pubmed/32605315
http://dx.doi.org/10.3390/cancers12071719

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