K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Southeast Asia has been the hotbed for the development of drug-resistant malaria parasites, including those with resistance to artemisinin combination therapy. While mutations in the kelch propeller domain (K13 mutations) are associated with artemisinin resistance, a range of evidence suggests that...

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Detalles Bibliográficos
Autores principales: Xiong, Aoli, Prakash, Prem, Gao, Xiaohong, Chew, Marvin, Tay, Ian Jun Jie, Woodrow, Charles J., Engelward, Bevin P., Han, Jongyoon, Preiser, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408483/
https://www.ncbi.nlm.nih.gov/pubmed/32755588
http://dx.doi.org/10.1016/j.celrep.2020.107996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408483/
https://www.ncbi.nlm.nih.gov/pubmed/32755588
http://dx.doi.org/10.1016/j.celrep.2020.107996

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