The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in homology-directed repair (HDR) is not well understood. Here, we identify the ubiquitin E3 ligase TRIP12 as negative regulator of PA...

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Detalles Bibliográficos
Autores principales: Gatti, Marco, Imhof, Ralph, Huang, Qingyao, Baudis, Michael, Altmeyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408484/
https://www.ncbi.nlm.nih.gov/pubmed/32755579
http://dx.doi.org/10.1016/j.celrep.2020.107985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408484/
https://www.ncbi.nlm.nih.gov/pubmed/32755579
http://dx.doi.org/10.1016/j.celrep.2020.107985

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