Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells

The persistence of long-lived memory plasma cells in the bone marrow depends on survival factors available in the bone marrow, which are provided in niches organized by stromal cells. Using an ex vivo system in which we supply the known survival signals, direct cell contact to stromal cells, and the...

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Detalles Bibliográficos
Autores principales: Cornelis, Rebecca, Hahne, Stefanie, Taddeo, Adriano, Petkau, Georg, Malko, Darya, Durek, Pawel, Thiem, Manja, Heiberger, Lukas, Peter, Lena, Mohr, Elodie, Klaeden, Cora, Tokoyoda, Koji, Siracusa, Francesco, Hoyer, Bimba Franziska, Hiepe, Falk, Mashreghi, Mir-Farzin, Melchers, Fritz, Chang, Hyun-Dong, Radbruch, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408492/
https://www.ncbi.nlm.nih.gov/pubmed/32755576
http://dx.doi.org/10.1016/j.celrep.2020.107982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408492/
https://www.ncbi.nlm.nih.gov/pubmed/32755576
http://dx.doi.org/10.1016/j.celrep.2020.107982

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