Cargando…

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms

A fundamental part of the immune response to infection or injury is leukocyte migration. Matrix metalloproteinases (MMPs) are a class of secreted or cell-bound endopeptidases, implicated in every step of the process of inflammatory cell migration. Hence, specific inhibition of MMPs is an interesting...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nuti, Elisa, Rossello, Armando, Cuffaro, Doretta, Camodeca, Caterina, Van Bael, Jens, van der Maat, Dries, Martens, Erik, Fiten, Pierre, Pereira, Rafaela Vaz Sousa, Ugarte-Berzal, Estefania, Gouwy, Mieke, Opdenakker, Ghislain, Vandooren, Jennifer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408547/ https://www.ncbi.nlm.nih.gov/pubmed/32645949 http://dx.doi.org/10.3390/cells9071634

Ejemplares similares

MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus
por: Ugarte-Berzal, Estefania, et al.
Publicado: (2019)

Endotoxemia shifts neutrophils with TIMP-free gelatinase B/MMP-9 from bone marrow to the periphery and induces systematic upregulation of TIMP-1
por: Vandooren, Jennifer, et al.
Publicado: (2017)

EDTA/gelatin zymography method to identify C1s versus activated MMP‐9 in plasma and immune complexes of patients with systemic lupus erythematosus
por: Ugarte‐Berzal, Estefania, et al.
Publicado: (2018)

Heterogeneity of serum gelatinases MMP-2 and MMP-9 isoforms and charge variants
por: Rossano, Rocco, et al.
Publicado: (2014)

Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids
por: Grillet, Bernard, et al.
Publicado: (2021)

Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B
por: Boon, Lise, et al.
Publicado: (2018)

Glycosylation of matrix metalloproteases and tissue inhibitors: present state, challenges and opportunities
por: Boon, Lise, et al.
Publicado: (2016)

Inhibition of Neutrophil Collagenase/MMP-8 and Gelatinase B/MMP-9 and Protection against Endotoxin Shock
por: Qiu, Zheng, et al.
Publicado: (2014)

Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study
por: Vandooren, Jennifer, et al.
Publicado: (2017)

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease
por: Ciccone, Lidia, et al.
Publicado: (2021)

Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening
por: Gimeno, Aleix, et al.
Publicado: (2021)

How to place the duality of specific MMP-9 inhibition for treatment of inflammatory bowel diseases into clinical opportunities?
por: Opdenakker, Ghislain, et al.
Publicado: (2022)

Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis
por: Ugarte-Berzal, Estefania, et al.
Publicado: (2018)

MMP-9 overexpression is associated with intragenic hypermethylation of MMP9 gene in melanoma
por: Falzone, Luca, et al.
Publicado: (2016)

The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
por: Li, Zhenshengnan, et al.
Publicado: (2023)

MMP2 and MMP9 associate with crescentic glomerulonephritis
por: Phillips, Tessa M., et al.
Publicado: (2017)

From ELISA to Immunosorbent Tandem Mass Spectrometry Proteoform Analysis: The Example of CXCL8/Interleukin-8
por: Metzemaekers, Mieke, et al.
Publicado: (2021)

Gelatinase B/Matrix Metalloproteinase-9 as Innate Immune Effector Molecule in Achalasia
por: Furuzawa-Carballeda, Janette, et al.
Publicado: (2018)

Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances
por: Huang, Hao
Publicado: (2018)

Immunoexpression of MMP-8 and MMP-9 in chronic subdural hematoma
por: Su, Gao-Jian, et al.
Publicado: (2022)

Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization
por: Cuffaro, Doretta, et al.
Publicado: (2023)

Correlation of MMP-3 and MMP-9 with Crohn’s Disease Activity in Children
por: Kofla-Dlubacz, Anna, et al.
Publicado: (2011)

Inhibition of MMP-2 and MMP-9 Activities by Limonium tetragonum Extract
por: Bae, Min-Joo, et al.
Publicado: (2016)

Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma
por: Goździalska, Anna, et al.
Publicado: (2016)

The involvement of MMP-2 and MMP-9 in heart exercise-related angiogenesis
por: Bellafiore, Marianna, et al.
Publicado: (2013)

Bruxism Throughout the Lifespan and Variants in MMP2, MMP9 and COMT
por: Vieira, Alexandre R., et al.
Publicado: (2020)

Quantification of matrix metalloproteinases MMP-8 and MMP-9 in gingival overgrowth
por: Orozco-Páez, Jennifer, et al.
Publicado: (2021)

The role of MMP-2 and MMP-9 in the metastasis and development of hypopharyngeal carcinoma
por: Song, Zhe, et al.
Publicado: (2019)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
por: Meneses-García, Abelardo, et al.
Publicado: (2008)

Activation of MMP‐9 by membrane type‐1 MMP/MMP‐2 axis stimulates tumor metastasis
por: Li, Zichen, et al.
Publicado: (2017)

Matrix Metalloproteinases MMP2 and MMP9 Are Produced in Early Stages of Kidney Morphogenesis but Only MMP9 Is Required for Renal Organogenesis In Vitro
por: Lelongt, Brigitte, et al.
Publicado: (1997)

The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer
por: Kudelski, Jacek, et al.
Publicado: (2023)

Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
por: Sakowicz, Agata, et al.
Publicado: (2018)

Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease
por: de Bruyn, Magali, et al.
Publicado: (2017)

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer
por: Huang, Xiwen, et al.
Publicado: (2021)

Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas
por: Mossböck, Georg, et al.
Publicado: (2010)

Meta-Analysis of MMP2, MMP3, and MMP9 Promoter Polymorphisms and Head and Neck Cancer Risk
por: Zhang, Caiyun, et al.
Publicado: (2013)

The MMP-1, MMP-2, and MMP-9 gene polymorphisms and susceptibility to bladder cancer: a meta-analysis
por: Yan, Yulan, et al.
Publicado: (2014)

Influence of TEGDMA monomer on MMP-2, MMP-8, and MMP-9 production and collagenase activity in pulp cells
por: Lovász, Bálint Viktor, et al.
Publicado: (2020)

The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes
por: Luchian, Ionut, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_803vha8q9pa2mdkbic2l9jag8m