Zebrafish Xenografts Unveil Sensitivity to Olaparib beyond BRCA Status

Poly (ADP-ribose) polymerase (PARP) inhibition in BRCA-mutated cells results in an incapacity to repair DNA damage, leading to cell death caused by synthetic lethality. Within the treatment options for advanced triple negative breast cancer, the PARP inhibitor olaparib is only given to patients with...

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Detalles Bibliográficos
Autores principales: Varanda, Ana Beatriz, Martins-Logrado, Ana, Godinho Ferreira, Miguel, Fior, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408583/
https://www.ncbi.nlm.nih.gov/pubmed/32630796
http://dx.doi.org/10.3390/cancers12071769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408583/
https://www.ncbi.nlm.nih.gov/pubmed/32630796
http://dx.doi.org/10.3390/cancers12071769

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