Uncoupling of DNA Replication and Centrosome Duplication Cycles Is a Primary Cause of Haploid Instability in Mammalian Somatic Cells

Mammalian haploid somatic cells are unstable and prone to diploidize, but the cause of haploid instability remains largely unknown. Previously, we found that mammalian haploid somatic cells suffer chronic centrosome loss stemming from the uncoupling of DNA replication and centrosome duplication cycl...

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Detalles Bibliográficos
Autores principales: Yoshizawa, Koya, Yaguchi, Kan, Uehara, Ryota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408703/
https://www.ncbi.nlm.nih.gov/pubmed/32850837
http://dx.doi.org/10.3389/fcell.2020.00721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408703/
https://www.ncbi.nlm.nih.gov/pubmed/32850837
http://dx.doi.org/10.3389/fcell.2020.00721

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