Aetiology of Myeloproliferative Neoplasms

Myeloproliferative neoplasms (MPNs) have estimated annual incidence rates for polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis of 0.84, 1.03, and 0.47 per 100,000. Prevalence is much higher, particularly for PV and ET, as mortality rates are relatively low. Patients...

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Autores principales: McMullin, Mary Frances, Anderson, Lesley Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408762/
https://www.ncbi.nlm.nih.gov/pubmed/32640679
http://dx.doi.org/10.3390/cancers12071810
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author McMullin, Mary Frances
Anderson, Lesley Ann
author_facet McMullin, Mary Frances
Anderson, Lesley Ann
author_sort McMullin, Mary Frances
collection PubMed
description Myeloproliferative neoplasms (MPNs) have estimated annual incidence rates for polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis of 0.84, 1.03, and 0.47 per 100,000. Prevalence is much higher, particularly for PV and ET, as mortality rates are relatively low. Patients are often concerned about why they developed an MPN and epidemiological studies enable the identification of potential causative factors. Previous work in small heterogeneous studies has identified a variety of risk factors associated with MPNs including family history of MPN, autoimmune conditions, some occupational exposures, and blood donation. At a population level, germline predisposition factors in various populations have been associated with MPNs. The pilot MOSAICC (Myeloproliferative Neoplasm: An In-depth Case-Control) study is one of the largest epidemiological studies in MPN ever carried out to date. It demonstrated the most effective methods for carrying out a significant epidemiological study in this patient group including the best way of recruiting controls, as well as how to evaluate occupational and lifestyle exposures, evaluate symptoms, and collect biological samples. Significant results linked to MPNs in the pilot study of 106 patients included smoking, obesity, and childhood socioeconomic status. The methodology is now in place for a much larger ongoing MOSAICC study which should provide further insight into the potential causes of MPNs.
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spelling pubmed-74087622020-08-13 Aetiology of Myeloproliferative Neoplasms McMullin, Mary Frances Anderson, Lesley Ann Cancers (Basel) Review Myeloproliferative neoplasms (MPNs) have estimated annual incidence rates for polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis of 0.84, 1.03, and 0.47 per 100,000. Prevalence is much higher, particularly for PV and ET, as mortality rates are relatively low. Patients are often concerned about why they developed an MPN and epidemiological studies enable the identification of potential causative factors. Previous work in small heterogeneous studies has identified a variety of risk factors associated with MPNs including family history of MPN, autoimmune conditions, some occupational exposures, and blood donation. At a population level, germline predisposition factors in various populations have been associated with MPNs. The pilot MOSAICC (Myeloproliferative Neoplasm: An In-depth Case-Control) study is one of the largest epidemiological studies in MPN ever carried out to date. It demonstrated the most effective methods for carrying out a significant epidemiological study in this patient group including the best way of recruiting controls, as well as how to evaluate occupational and lifestyle exposures, evaluate symptoms, and collect biological samples. Significant results linked to MPNs in the pilot study of 106 patients included smoking, obesity, and childhood socioeconomic status. The methodology is now in place for a much larger ongoing MOSAICC study which should provide further insight into the potential causes of MPNs. MDPI 2020-07-06 /pmc/articles/PMC7408762/ /pubmed/32640679 http://dx.doi.org/10.3390/cancers12071810 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
McMullin, Mary Frances
Anderson, Lesley Ann
Aetiology of Myeloproliferative Neoplasms
title Aetiology of Myeloproliferative Neoplasms
title_full Aetiology of Myeloproliferative Neoplasms
title_fullStr Aetiology of Myeloproliferative Neoplasms
title_full_unstemmed Aetiology of Myeloproliferative Neoplasms
title_short Aetiology of Myeloproliferative Neoplasms
title_sort aetiology of myeloproliferative neoplasms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408762/
https://www.ncbi.nlm.nih.gov/pubmed/32640679
http://dx.doi.org/10.3390/cancers12071810
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