Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results

Some 10–50% of Lynch-suspected cases with abnormal immunohistochemical (IHC) staining remain without any identifiable germline mutation of DNA mismatch repair (MMR) genes. MMR proteins form heterodimeric complexes, giving rise to distinct IHC patterns when mutant. Potential reasons for not finding a...

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Detalles Bibliográficos
Autores principales: Olkinuora, Alisa, Gylling, Annette, Almusa, Henrikki, Eldfors, Samuli, Lepistö, Anna, Mecklin, Jukka-Pekka, Nieminen, Taina Tuulikki, Peltomäki, Päivi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408769/
https://www.ncbi.nlm.nih.gov/pubmed/32660107
http://dx.doi.org/10.3390/cancers12071853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408769/
https://www.ncbi.nlm.nih.gov/pubmed/32660107
http://dx.doi.org/10.3390/cancers12071853

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