Cargando…

Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a

Gliomas are fast growing and highly invasive brain tumors, characterized by tumor microenvironment acidification that drives glioma cell growth and migration. Channels containing Acid-sensing Ion Channel 1a subunit (ASIC1a) mediate amiloride-sensitive cation influx in late stage glioma cells, but no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bychkov, Maxim, Shulepko, Mikhail, Osmakov, Dmitry, Andreev, Yaroslav, Sudarikova, Anastasia, Vasileva, Valeria, Pavlyukov, Marat S., Latyshev, Yaroslav A., Potapov, Alexander A., Kirpichnikov, Mikhail, Shenkarev, Zakhar O., Lyukmanova, Ekaterina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408772/ https://www.ncbi.nlm.nih.gov/pubmed/32650495 http://dx.doi.org/10.3390/cancers12071837

Ejemplares similares

ASIC1a Inhibitor mambalgin-2 Suppresses the Growth of Leukemia Cells by Cell Cycle Arrest
por: Bychkov, M. L., et al.
Publicado: (2020)

Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer
por: Sudarikova, Anastasia V., et al.
Publicado: (2022)

Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors
por: Bychkov, Maxim, et al.
Publicado: (2019)

Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis
por: Bychkov, Maxim L., et al.
Publicado: (2021)

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2023)

Recombinant Production, NMR Solution Structure, and Membrane Interaction of the Phα1β Toxin, a TRPA1 Modulator from the Brazilian Armed Spider Phoneutria nigriventer
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2023)

New Three-Finger Protein from Starfish Asteria rubens Shares Structure and Pharmacology with Human Brain Neuromodulator Lynx2
por: Paramonov, Alexander S., et al.
Publicado: (2022)

Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline
por: Osmakov, Dmitry I., et al.
Publicado: (2019)

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer
por: Bychkov, Maxim L., et al.
Publicado: (2021)

Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain
por: Kulbatskii, Dmitrii, et al.
Publicado: (2021)

Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors
por: Paramonov, Alexander S., et al.
Publicado: (2020)

Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3)
por: Osmakov, Dmitry I., et al.
Publicado: (2019)

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2016)

Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors
por: Shenkarev, Zakhar O., et al.
Publicado: (2022)

Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes
por: Bychkov, Maxim L., et al.
Publicado: (2022)

Caloric restriction triggers morphofunctional remodeling of astrocytes and enhances synaptic plasticity in the mouse hippocampus
por: Popov, Alexander, et al.
Publicado: (2020)

Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels
por: Osmakov, Dmitry I., et al.
Publicado: (2020)

Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect
por: Sun, Demeng, et al.
Publicado: (2018)

Aβ1-42 Accumulation Accompanies Changed Expression of Ly6/uPAR Proteins, Dysregulation of the Cholinergic System, and Degeneration of Astrocytes in the Cerebellum of Mouse Model of Early Alzheimer Disease
por: Bychkov, Maxim L., et al.
Publicado: (2023)

Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins
por: Zaigraev, Maxim M., et al.
Publicado: (2022)

Human SLURP-1 and SLURP-2 Proteins Acting on Nicotinic Acetylcholine Receptors Reduce Proliferation of Human Colorectal Adenocarcinoma HT-29 Cells
por: Lyukmanova, E. N., et al.
Publicado: (2014)

Cell-Free Expression of Sodium Channel Domains for Pharmacology Studies. Noncanonical Spider Toxin Binding Site in the Second Voltage-Sensing Domain of Human Na(v)1.4 Channel
por: Myshkin, Mikhail Yu., et al.
Publicado: (2019)

Cell-free Production of the Extracellular Domain of the Nicotinic Acetylcholine Receptor
por: Lyukmanova, E.N., et al.
Publicado: (2009)

Lynx1 Prevents Long-Term Potentiation Blockade and Reduction of Neuromodulator Expression Caused by Aβ1-42 and JNK Activation
por: Bychkov, M. L., et al.
Publicado: (2018)

Retinoic Acid-Differentiated Neuroblastoma SH-SY5Y Is an Accessible In Vitro Model to Study Native Human Acid-Sensing Ion Channels 1a (ASIC1a)
por: Kalinovskii, Aleksandr P., et al.
Publicado: (2022)

Dual Modulator of ASIC Channels and GABA(A) Receptors from Thyme Alters Fear-Related Hippocampal Activity
por: Kalinovskii, Aleksandr P., et al.
Publicado: (2023)

Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes
por: Bychkov, M. L., et al.
Publicado: (2022)

N-Terminal Fusion Tags for Effective Production of G-Protein-Coupled Receptors in Bacterial Cell-Free Systems
por: Lyukmanova, E.N., et al.
Publicado: (2012)

Lipid–Protein Nanodiscs Offer New Perspectives for Structural and Functional Studies of Water-Soluble Membrane-Active Peptides
por: Shenkarev, Z. O., et al.
Publicado: (2014)

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors
por: Lyukmanova, E. N., et al.
Publicado: (2016)

Endogenous Isoquinoline Alkaloids Agonists of Acid-Sensing Ion Channel Type 3
por: Osmakov, Dmitry I., et al.
Publicado: (2017)

Spider toxin inhibits gating pore currents underlying periodic paralysis
por: Männikkö, Roope, et al.
Publicado: (2018)

Combination of TRAIL with Bortezomib Shifted Apoptotic Signaling from DR4 to DR5 Death Receptor by Selective Internalization and Degradation of DR4
por: Bychkov, Maxim L., et al.
Publicado: (2014)

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities
por: Osmakov, Dmitry I., et al.
Publicado: (2022)

Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1
por: Sun, Demeng, et al.
Publicado: (2020)

(Z,Z)-Selanediylbis(2-propenamides): Novel Class of Organoselenium Compounds with High Glutathione Peroxidase-Like Activity. Regio- and Stereoselective Reaction of Sodium Selenide with 3-Trimethylsilyl-2-propynamides
por: V. Andreev, Mikhail, et al.
Publicado: (2020)

DR5-Selective TRAIL Variant DR5-B Functionalized with Tumor-Penetrating iRGD Peptide for Enhanced Antitumor Activity against Glioblastoma
por: Yagolovich, Anne V., et al.
Publicado: (2022)

Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis
por: Vasileva, Valeria, et al.
Publicado: (2021)

Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds
por: Andreev, Yaroslav A., et al.
Publicado: (2018)

The implications of histamine metabolism and signaling in renal function
por: Sudarikova, Anastasia V., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3ph4nrdoot5ofr4euubt1ihapi