Peri‐arterial pathways for clearance of α‐Synuclein and tau from the brain: Implications for the pathogenesis of dementias and for immunotherapy

INTRODUCTION: Accumulation of amyloid beta (Aβ), α‐synuclein (αSyn), and tau in dementias indicates their age‐related failure of elimination from the brain. Aβ is eliminated along basement membranes in walls of cerebral arterioles and leptomeningeal arteries (intramural peri‐arterial drainage [IPAD]...

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Detalles Bibliográficos
Autores principales: Nimmo, Jacqui, Johnston, David A., Dodart, J. C., MacGregor‐Sharp, Matthew T., Weller, Roy O., Nicoll, James A. R., Verma, Ajay, Carare, Roxana O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Neuroimaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409108/
https://www.ncbi.nlm.nih.gov/pubmed/32782922
http://dx.doi.org/10.1002/dad2.12070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409108/
https://www.ncbi.nlm.nih.gov/pubmed/32782922
http://dx.doi.org/10.1002/dad2.12070

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