Accurate In-Vivo Quantification of CD19 CAR-T Cells after Treatment with Axicabtagene Ciloleucel (Axi-Cel) and Tisagenlecleucel (Tisa-Cel) Using Digital PCR

Immunotherapy with CD19-specific chimeric antigen receptor (CAR-) T cells has shown excellent efficacy in relapsed/refractory B-cell cancers. The in vivo expansion and persistence of CAR-T cells after infusion are important response- and toxicity-determining variables, but diagnostic tools are large...

Descripción completa

Detalles Bibliográficos
Autores principales: Badbaran, Anita, Berger, Carolina, Riecken, Kristoffer, Kruchen, Anne, Geffken, Maria, Müller, Ingo, Kröger, Nicolaus, Ayuk, Francis A., Fehse, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409173/
https://www.ncbi.nlm.nih.gov/pubmed/32698364
http://dx.doi.org/10.3390/cancers12071970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409173/
https://www.ncbi.nlm.nih.gov/pubmed/32698364
http://dx.doi.org/10.3390/cancers12071970

Ejemplares similares