Inhibition of Methyltransferase DOT1L Sensitizes to Sorafenib Treatment AML Cells Irrespective of MLL-Rearrangements: A Novel Therapeutic Strategy for Pediatric AML

Pediatric acute myeloid leukemia (AML) is an aggressive malignancy with poor prognosis for which there are few effective targeted approaches, despite the numerous genetic alterations, including MLL gene rearrangements (MLL-r). The histone methyltransferase DOT1L is involved in supporting the prolife...

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Detalles Bibliográficos
Autores principales: Lonetti, Annalisa, Indio, Valentina, Laginestra, Maria Antonella, Tarantino, Giuseppe, Chiarini, Francesca, Astolfi, Annalisa, Bertuccio, Salvatore N., Martelli, Alberto M., Locatelli, Franco, Pession, Andrea, Masetti, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409321/
https://www.ncbi.nlm.nih.gov/pubmed/32698374
http://dx.doi.org/10.3390/cancers12071972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409321/
https://www.ncbi.nlm.nih.gov/pubmed/32698374
http://dx.doi.org/10.3390/cancers12071972

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