Overexpression of MicroRNA-133a Inhibits Apoptosis and Autophagy in a Cell Model of Parkinson’s Disease by Downregulating Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1)

BACKGROUND: Parkinson’s disease (PD) is a movement disorder. microRNA (miR)-133 expression is reduced in PD patients and in mice with a dopamine neuron deficiency. We aimed to identify the mechanism of miR-133a in apoptosis and autophagy in PD. MATERIAL/METHODS: The optimal concentration of MPP(+) (...

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Detalles Bibliográficos
Autores principales: Lu, Wusheng, Lin, Jinhuang, Zheng, Dequan, Hong, Chunyong, Ke, Laishun, Wu, Xinyu, Chen, Peineng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409387/
https://www.ncbi.nlm.nih.gov/pubmed/32713934
http://dx.doi.org/10.12659/MSM.922032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409387/
https://www.ncbi.nlm.nih.gov/pubmed/32713934
http://dx.doi.org/10.12659/MSM.922032

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