Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia

MicroRNA-124 (miR-124), a brain-enriched microRNA, is known to regulate microglial quiescence. Psychostimulants such as cocaine have been shown to activate microglia by downregulating miR-124, leading, in turn, to neuroinflammation. We thus rationalized that restoring the levels of miR-124 could fun...

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Detalles Bibliográficos
Autores principales: Chivero, Ernest T., Liao, Ke, Niu, Fang, Tripathi, Ashutosh, Tian, Changhai, Buch, Shilpa, Hu, Guoku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409518/
https://www.ncbi.nlm.nih.gov/pubmed/32850781
http://dx.doi.org/10.3389/fcell.2020.00573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409518/
https://www.ncbi.nlm.nih.gov/pubmed/32850781
http://dx.doi.org/10.3389/fcell.2020.00573

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