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Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication?
[Image: see text] SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys(189)–X–X–Cys(192)–X(n)–Cys(224)–X–Cys(226)) and a classic catalytic site (Cys(111)–His(272)–Asp(286)), which play key roles for viral replication and hence represent promising drug targets. In this Viewpo...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409920/ https://www.ncbi.nlm.nih.gov/pubmed/33062954 http://dx.doi.org/10.1021/acsptsci.0c00093 |