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Selective Upregulation of CTLA-4 on CD8(+) T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection
HLA-B*35Px is associated with HIV-1 disease rapid progression to AIDS. However, the mechanism(s) underlying this deleterious effect of this HLA allele on HIV-1 infection outcome has not fully understood. CD8(+) T cells play a crucial role to control the viral replication but impaired CD8(+) T cells...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410205/ https://www.ncbi.nlm.nih.gov/pubmed/32760139 http://dx.doi.org/10.1371/journal.ppat.1008696 |