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scPADGRN: A preconditioned ADMM approach for reconstructing dynamic gene regulatory network using single-cell RNA sequencing data

Disease development and cell differentiation both involve dynamic changes; therefore, the reconstruction of dynamic gene regulatory networks (DGRNs) is an important but difficult problem in systems biology. With recent technical advances in single-cell RNA sequencing (scRNA-seq), large volumes of sc...

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Detalles Bibliográficos
Autores principales: Zheng, Xiao, Huang, Yuan, Zou, Xiufen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410337/
https://www.ncbi.nlm.nih.gov/pubmed/32716923
http://dx.doi.org/10.1371/journal.pcbi.1007471