Cargando…

Protective Role of Astrocyte-Derived Exosomal microRNA-361 in Cerebral Ischemic-Reperfusion Injury by Regulating the AMPK/mTOR Signaling Pathway and Targeting CTSB

BACKGROUND: Evidence has shown that microRNAs (miRNAs) are implicated in ischemic diseases. Therefore, the aim of the present study was to identify the functions of astrocyte (ATC)-derived exosomal miR-361 on cerebral ischemic-reperfusion (I/R) injury. METHODS: A rat model of cerebral I/R injury was...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bu, Xiancong, Li, Dong, Wang, Feng, Sun, Qimeng, Zhang, Zixian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410492/ https://www.ncbi.nlm.nih.gov/pubmed/32801720 http://dx.doi.org/10.2147/NDT.S260748

Ejemplares similares

Protective Role of Astrocyte-Derived Exosomal microRNA-361 in Cerebral Ischemic-Reperfusion Injury by Regulating the AMPK/mTOR Signaling Pathway and Targeting CTSB [Retraction]
Publicado: (2022)

Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy
por: Deng, Yang, et al.
Publicado: (2022)

Myocardial Ischemic Postconditioning Promotes Autophagy against Ischemia Reperfusion Injury via the Activation of the nNOS/AMPK/mTOR Pathway
por: Hao, Maojuan, et al.
Publicado: (2017)

Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway
por: Sun, Xiaowei, et al.
Publicado: (2020)

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway
por: Wang, Li, et al.
Publicado: (2022)

The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion
por: Yang, Liying, et al.
Publicado: (2017)

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
por: Chun, Yoomi, et al.
Publicado: (2021)

Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway
por: Zhu, Jiang, et al.
Publicado: (2019)

PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway
por: Wu, Liwei, et al.
Publicado: (2021)

Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway
por: Yang, Yi, et al.
Publicado: (2019)

CTSB Knockdown Inhibits Proliferation and Tumorigenesis in HL-60 Cells
por: Peng, Sida, et al.
Publicado: (2021)

TRPC6 Attenuates Cortical Astrocytic Apoptosis and Inflammation in Cerebral Ischemic/Reperfusion Injury
por: Liu, Lu, et al.
Publicado: (2021)

Annexin A1 protects against cerebral ischemia–reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway
por: Xu, Xin, et al.
Publicado: (2021)

Central Exercise Action Increases the AMPK and mTOR Response to Leptin
por: Ropelle, Eduardo R., et al.
Publicado: (2008)

TFEC contributes to cardiac hypertrophy by inhibiting AMPK/mTOR signaling
por: Zhao, Ting, et al.
Publicado: (2021)

Antioxidant Compound, Oxyresveratrol, Inhibits APP Production through the AMPK/ULK1/mTOR-Mediated Autophagy Pathway in Mouse Cortical Astrocytes
por: Rahman, Md. Ataur, et al.
Publicado: (2021)

Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens
por: Brunton, Jason, et al.
Publicado: (2013)

Retraction: Central Exercise Action Increases the AMPK and mTOR Response to Leptin
Publicado: (2018)

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
por: Su, Yuan, et al.
Publicado: (2019)

Glucose activates the primordial follicle through the AMPK/mTOR signaling pathway
por: Xu, Shengyu, et al.
Publicado: (2020)

How does mTOR sense glucose starvation? AMPK is the usual suspect
por: Leprivier, Gabriel, et al.
Publicado: (2020)

Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
por: Ramirez Reyes, Josué M. J., et al.
Publicado: (2021)

Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation
por: Audet-Walsh, Étienne, et al.
Publicado: (2021)

Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling
por: Leung, A., et al.
Publicado: (2023)

mTOR/autophagy pathway in the hippocampus of rats suffering intermittent hypoxia preconditioning and global cerebral ischemia-reperfusion
por: Zhao, Ya-Ning, et al.
Publicado: (2017)

Dihydromyricetin Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting SPHK1/mTOR Signaling and Targeting Ferroptosis
por: Xie, Jiangbo, et al.
Publicado: (2022)

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway
por: Wang, Jin-Feng, et al.
Publicado: (2018)

Study on the Mechanism of mTOR-Mediated Autophagy during Electroacupuncture Pretreatment against Cerebral Ischemic Injury
por: Wu, Zhou-Quan, et al.
Publicado: (2016)

Inhibition of mTOR signaling Confers Protection against Cerebral Ischemic Injury in Acute Hyperglycemic Rats
por: Hei, Changchun, et al.
Publicado: (2017)

Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury
por: Liu, Dong, et al.
Publicado: (2019)

A systems study reveals concurrent activation of AMPK and mTOR by amino acids
por: Pezze, Piero Dalle, et al.
Publicado: (2016)

Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway
por: Liu, Jiayu, et al.
Publicado: (2018)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes
por: Sukumaran, Abitha, et al.
Publicado: (2020)

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
por: Feng, Xiaofeng, et al.
Publicado: (2020)

Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis
por: Su, Shuai, et al.
Publicado: (2021)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

Coordination of the AMPK, Akt, mTOR, and p53 Pathways under Glucose Starvation
por: Zhou, Yifan, et al.
Publicado: (2022)

Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway
por: Liang, Hao-Yu, et al.
Publicado: (2022)

Inhibition of autophagy by CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR pathway contributes to ischemic postconditioning-induced neuroprotection against cerebral ischemia-reperfusion injury
por: Yao, Yuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kj62h2k6813j8efpekjrdr3a7c