A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular mechanism for COVID-19 that provides therapeutic intervention points that can be addressed with existing FDA-approved pharmaceuticals. The entry point for the virus is ACE2, which is a c...

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Detalles Bibliográficos
Autores principales: Garvin, Michael R, Alvarez, Christiane, Miller, J Izaak, Prates, Erica T, Walker, Angelica M, Amos, B Kirtley, Mast, Alan E, Justice, Amy, Aronow, Bruce, Jacobson, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410499/
https://www.ncbi.nlm.nih.gov/pubmed/32633718
http://dx.doi.org/10.7554/eLife.59177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410499/
https://www.ncbi.nlm.nih.gov/pubmed/32633718
http://dx.doi.org/10.7554/eLife.59177

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