Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN‐null triple negative breast cancer

Triple‐negative breast cancer (TNBC) has poorer prognosis compared to other types of breast cancers due to the lack of effective therapies and markers for patient stratification. Loss of PTEN tumor suppressor gene expression is a frequent event in TNBC, resulting in over‐activation of the PI 3‐kinas...

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Detalles Bibliográficos
Autores principales: Zecchin, Davide, Moore, Christopher, Michailidis, Fanourios, Horswell, Stuart, Rana, Sareena, Howell, Michael, Downward, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411640/
https://www.ncbi.nlm.nih.gov/pubmed/32672423
http://dx.doi.org/10.15252/emmm.202011987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411640/
https://www.ncbi.nlm.nih.gov/pubmed/32672423
http://dx.doi.org/10.15252/emmm.202011987

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