Synthesis and Biological Evaluation of Analogs of Didehydroepiandrosterone as Potential New Anticancer Agents

The synthesis, cytotoxicity and inhibition of CDK8 by thirteen analogs of cortistatin A are reported. These efforts revealed that the analogs with either a 6- or 7-isoquinoline or 5-indole side chain in the 17-position are the most promising anti-proliferative agents. These compounds showed potent c...

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Detalles Bibliográficos
Autores principales: J. Solum, Eirik, Liekens, Sandra, Hansen, Trond Vidar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412091/
https://www.ncbi.nlm.nih.gov/pubmed/32635325
http://dx.doi.org/10.3390/molecules25133052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412091/
https://www.ncbi.nlm.nih.gov/pubmed/32635325
http://dx.doi.org/10.3390/molecules25133052

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