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The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice
HSV-2 (Herpes simplex virus type 2) is a critical viral agent that mainly causes genital herpes and life-long latent infection in the dorsal root ganglia. Gene modification via CRISPR/Cas9 Clustered regularly interspaced short palindromic repeat sequences/CRISPR associated 9) was used here to constr...
Autores principales: | Liu, Lei, Cheng, Jishuai, Mou, Tangwei, Zhang, Ying, Xu, Xingli, Zhang, Jingjing, Li, Xueqi, Feng, Xiao, Xu, Xiangxiong, Liao, Yun, Fan, Shengtao, Wang, Lichun, Jiang, Guorun, Li, Qihan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412103/ https://www.ncbi.nlm.nih.gov/pubmed/32708847 http://dx.doi.org/10.3390/v12070770 |
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