Cargando…

The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice

HSV-2 (Herpes simplex virus type 2) is a critical viral agent that mainly causes genital herpes and life-long latent infection in the dorsal root ganglia. Gene modification via CRISPR/Cas9 Clustered regularly interspaced short palindromic repeat sequences/CRISPR associated 9) was used here to constr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Lei, Cheng, Jishuai, Mou, Tangwei, Zhang, Ying, Xu, Xingli, Zhang, Jingjing, Li, Xueqi, Feng, Xiao, Xu, Xiangxiong, Liao, Yun, Fan, Shengtao, Wang, Lichun, Jiang, Guorun, Li, Qihan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412103/ https://www.ncbi.nlm.nih.gov/pubmed/32708847 http://dx.doi.org/10.3390/v12070770

Ejemplares similares

A HSV1 mutant leads to an attenuated phenotype and induces immunity with a protective effect
por: Xu, Xingli, et al.
Publicado: (2020)

HSV-1 Infection of Epithelial Dendritic Cells Is a Critical Strategy for Interfering with Antiviral Immunity
por: Gao, Yang, et al.
Publicado: (2022)

Immunological Identification and Characterization of the Capsid Scaffold Protein Encoded by UL26.5 of Herpes Simplex Virus Type 2
por: Li, Xueqi, et al.
Publicado: (2021)

Understanding global changes of the mouse brain proteome after vaginal infection with HSV-2 using a label-free shotgun approach
por: Cheng, Jishuai, et al.
Publicado: (2022)

Mechanism for the lethal effect of enterovirus A71 intracerebral injection in neonatal mice
por: Feng, Min, et al.
Publicado: (2019)

Immunological Study of Combined Administration of SARS-CoV-2 DNA Vaccine and Inactivated Vaccine
por: Meng, Ziyan, et al.
Publicado: (2022)

The role of multiple SARS-CoV-2 viral antigens in a vaccine-induced integrated immune response
por: Zhang, Ying, et al.
Publicado: (2021)

Evaluation of Immunogenicity and Clinical Protection of SARS-CoV-2 S1 and N Antigens in Syrian Golden Hamster
por: Niu, Zhenye, et al.
Publicado: (2022)

Analysis of the Protective Immunity Induced by Herpes Simplex Virus 1 Strain M3 with an Attenuated Phenotype Due to Mutations in the Viral ul7, ul41, and LAT Genes
por: Xu, Xingli, et al.
Publicado: (2017)

Ameliorated immunity elicited by intradermal inoculation in individuals vaccinated with inactivated SARS-CoV-2 vaccine
por: Fan, Shengtao, et al.
Publicado: (2021)

Attenuated Phenotype and Immunogenic Characteristics of a Mutated Herpes Simplex Virus 1 Strain in the Rhesus Macaque
por: Fan, Shengtao, et al.
Publicado: (2018)

Characterization of the Immunologic Phenotype of Dendritic Cells Infected With Herpes Simplex Virus 1
por: Zhang, Jingjing, et al.
Publicado: (2022)

Role of innate lymphoid cells and dendritic cells in intradermal immunization of the enterovirus antigen
por: Fan, Shengtao, et al.
Publicado: (2019)

Author Correction: Role of innate lymphoid cells and dendritic cells in intradermal immunization of the enterovirus antigen
por: Fan, Shengtao, et al.
Publicado: (2019)

HSV-1 tegument protein and the development of its genome editing technology
por: Xu, Xingli, et al.
Publicado: (2016)

Intensified antibody response elicited by boost suggests immune memory in individuals administered two doses of SARS-CoV-2 inactivated vaccine
por: Liao, Yun, et al.
Publicado: (2021)

The mutated tegument protein UL7 attenuates the virulence of herpes simplex virus 1 by reducing the modulation of α-4 gene transcription
por: Xu, Xingli, et al.
Publicado: (2016)

Waning antibodies from inactivated SARS-CoV-2 vaccination offer protection against infection without antibody-enhanced immunopathology in rhesus macaque pneumonia models
por: Li, Dandan, et al.
Publicado: (2021)

The Modulation of Phosphatase Expression Impacts the Proliferation Efficiency of HSV-1 in Infected Astrocytes
por: Yue, Lei, et al.
Publicado: (2013)

The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features
por: Fan, Shengtao, et al.
Publicado: (2017)

Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein
por: Wang, Lei, et al.
Publicado: (2010)

Dual impacts of a glycan shield on the envelope glycoprotein B of HSV-1: evasion from human antibodies in vivo and neurovirulence
por: Fukui, Ayano, et al.
Publicado: (2023)

Dual miRNA Targeting Restricts Host Range and Attenuates Neurovirulence of Flaviviruses
por: Tsetsarkin, Konstantin A., et al.
Publicado: (2015)

Development of a Bicistronic Yellow Fever Live Attenuated Vaccine with Reduced Neurovirulence and Viscerotropism
por: Wang, Hong-Jiang, et al.
Publicado: (2022)

Long-Term Cross Immune Response in Mice following Heterologous Prime-Boost COVID-19 Vaccination with Full-Length Spike mRNA and Recombinant S1 Protein
por: Li, Dandan, et al.
Publicado: (2023)

Preclinical safety evaluation of a bivalent inactivated EV71-CA16 vaccine in mice immunized intradermally
por: Liao, Yun, et al.
Publicado: (2023)

Polyomavirus Wakes Up and Chooses Neurovirulence
por: Butic, Arrienne B., et al.
Publicado: (2023)

Preclinical immunological evaluation of an intradermal heterologous vaccine against SARS-CoV-2 variants
por: Fan, Shengtao, et al.
Publicado: (2022)

Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus
por: Gupta, Paridhi, et al.
Publicado: (2017)

A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype
por: Song, Guang-Yuan, et al.
Publicado: (2023)

Duck Tembusu virus exhibits neurovirulence in BALB/c mice
por: Li, Shuang, et al.
Publicado: (2013)

The safety and immunogenicity of an inactivated SARS-CoV-2 vaccine in Chinese adults aged 18–59 years: A phase I randomized, double-blinded, controlled trial
por: Pu, Jing, et al.
Publicado: (2021)

NEUROVIRULENCE AND PERSISTENCY OF MOUSE HEPATITIS VIRUSES IN RATS
por: Wege, H., et al.
Publicado: (1980)

Herpes Simplex Virus Type 1–Encoded miR-H2-3p Manipulates Cytosolic DNA–Stimulated Antiviral Innate Immune Response by Targeting DDX41
por: Duan, Yongzhong, et al.
Publicado: (2019)

RNA Structure in the 5′ Untranslated Region of Enterovirus D68 Strains with Differing Neurovirulence Phenotypes
por: Eastman, Connor, et al.
Publicado: (2023)

Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
por: Xu, Xingli, et al.
Publicado: (2019)

Antibody escape by polyomavirus capsid mutation facilitates neurovirulence
por: Lauver, Matthew D, et al.
Publicado: (2020)

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
por: Bauer, Lisa, et al.
Publicado: (2022)

The Ablation of Envelope Protein Glycosylation Enhances the Neurovirulence of ZIKV and Cell Apoptosis in Newborn Mice
por: Guo, Yanqing, et al.
Publicado: (2021)

Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence
por: Phillips, Joanna J., et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_hivtdc8p1djmd8m3r950kdimcf