Cargando…
Poly-arginine-18 (R18) Confers Neuroprotection through Glutamate Receptor Modulation, Intracellular Calcium Reduction, and Preservation of Mitochondrial Function
Recent studies have highlighted that a novel class of neuroprotective peptide, known as cationic arginine-rich peptides (CARPs), have intrinsic neuroprotective properties and are particularly effective anti-excitotoxic agents. As such, the present study investigated the mechanisms underlying the ant...
Autores principales: | MacDougall, Gabriella, Anderton, Ryan S., Trimble, Amy, Mastaglia, Frank L., Knuckey, Neville W., Meloni, Bruno P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412265/ https://www.ncbi.nlm.nih.gov/pubmed/32610439 http://dx.doi.org/10.3390/molecules25132977 |
Ejemplares similares
-
Proteomic analysis of cortical neuronal cultures treated with poly-arginine peptide-18 (R18) and exposed to glutamic acid excitotoxicity
por: MacDougall, Gabriella, et al.
Publicado: (2019) -
Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell hemolysis
por: Edwards, Adam B., et al.
Publicado: (2022) -
Impact of poly-arginine peptides R18D and R18 on alteplase and tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis
por: Meloni, Bruno P., et al.
Publicado: (2022) -
Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies
por: Milani, Diego, et al.
Publicado: (2018) -
Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat
por: Edwards, Adam B., et al.
Publicado: (2018)