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Tetherin downmodulation by SIVmac Nef lost with the H196Q escape variant is restored by an upstream variant
The H(196) residue in SIVmac239 Nef is conserved across the majority of HIV and SIV isolates, lies immediately adjacent to the AP-2 (adaptor protein 2) binding di-leucine domain (ExxxLM(195)), and is critical for several described AP-2 dependent Nef functions, including the downregulation of tetheri...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413475/ https://www.ncbi.nlm.nih.gov/pubmed/32764749 http://dx.doi.org/10.1371/journal.pone.0225420 |