Zinc-mediated conformational preselection mechanism in the allosteric control of DNA binding to the zinc transcriptional regulator (ZitR)

The zinc transcriptional regulator (ZitR) functions as a metalloregulator that fine tunes transcriptional regulation through zinc-dependent DNA binding. However, the molecular mechanism of zinc-driven allosteric control of the DNA binding to ZitR remains elusive. Here, we performed enhanced sampling...

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Detalles Bibliográficos
Autores principales: He, Xinheng, Ni, Duan, Zhang, Hao, Li, Xinyi, Zhang, Jian, Fu, Qiang, Liu, Yaqin, Lu, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413533/
https://www.ncbi.nlm.nih.gov/pubmed/32764589
http://dx.doi.org/10.1038/s41598-020-70381-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413533/
https://www.ncbi.nlm.nih.gov/pubmed/32764589
http://dx.doi.org/10.1038/s41598-020-70381-8

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